*What is this drug used for?

• It is used to ease pain.

• It is only to be used when around-the-clock (continuous) care is needed for a long time. It is also only to be used when other pain drugs do not treat your pain well enough or you cannot take them. It is mainly used for pain relief in patients with severe cancer pain.

*How is this drug best taken?

1. Swallow whole. Do not chew, break, crush, or dissolve before swallowing.

2. Adults should take it every 12 hours.

*Warning and caution！

1. What do I need to tell my doctor BEFORE I take this drug?

• If you are allergic to morphine or any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had

• If you have any of these health problems: Lung or breathing problems like asthma, trouble breathing, or sleep apnea; high levels of carbon dioxide in the blood; or stomach or bowel block or narrowing. History of epilepsy.

• If you are taking or have taken any medication in the past 14 days, such as antidepressants, anticoagulants, etc.

• If you are breast-feeding. Do not breast-feed while you take this drug.

2. What are some things I need to know or do while I take this drug?

• Do not take with alcohol or products that have alcohol.

• Undiagnosed pain, as far as possible do not use this product, so as not to cover up the disease, miss the diagnosis.

• To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.

• If you have been taking this drug for a long time or at high doses, it may not work as well and you may need higher doses to get the same effect. Call your doctor if this drug stops working well. Do not take more than ordered.

• If you are 65 or older, use this drug with care. You could have more side effects.

* What are some side effects that I need to call my doctor about right away?

1. Long-term or regular use of opioid drugs like this drug may lead to dependence. Lowering the dose or stopping this drug all of a sudden may cause a greater risk of withdrawal or other severe problems. Talk to your doctor before you lower the dose or stop this drug. You will need to follow your doctor’s instructions. Tell your doctor if you have more pain, mood changes, thoughts of suicide, or any other bad effects.

2. This drug may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking this drug, call your doctor right away.

3. Signs of an allergic reaction. For example: redness, swelling, heat, pain, etc.

4. Very bad dizziness or passing out.

5. Trouble breathing, Shortness of breath, slow breathing, or shallow breathing.

6. Feeling very sleepy.

7. Gastrointestinal discomfort such as severe abdominal pain, vomiting, and constipation can be very serious.

8. Chest pain or pressure or a fast heartbeat.

* What do I do if I miss a dose?

1. Skip the missed dose and go back to your normal time.

2. Do not take 2 doses at the same time or extra doses.

*Storage conditions

1. Store at room temperature.

2. Protect from light.

3. Store in a dry place. Do not store in a bathroom.

4. Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.

Reference:

1. Morphine Sulfate Sustained-release Tablets Package Insert

2. Applied Pharmaceutical Practice（2009）

3. Up to date